Drupal and Adobe Flex are perfect partners. The key to making the two systems communicate is understanding the Drupal Services Module. This provides the communication layer between Flex and the Drupal API / Database. The services module comes with some useful built in facilities such as loading nodes, accessing the taxonomy. Extending the module with your own services is really easy. The code powering the module is rudimentary for anyone familiar with module development.
Flex Documentation
The Drupal site has some excellent Flex documentation now including some thorough Flex screencasts which represent the best fast track route to understanding Flex builder and Drupal integration
Getting Started
This Flex Drupal Tutorial talks through how to get the modules required configured and how to read and write data with Drupal and Flex.
Useful Screencasts
Flex Related Articles
Sample applications (http://www.picnik.com/app)
http://www.quietlyscheming.com/blog/components/animated-dragtile-compone... interesting tutorials
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